Induction of Mycobacterial Resistance to Quinolone Class Antimicrobials
نویسندگان
چکیده
منابع مشابه
Induction of mycobacterial resistance to quinolone class antimicrobials.
An agar plate assay was developed for detecting the induction of drug-resistant mycobacterial mutants during exposure to inhibitors of DNA gyrase. When Mycobacterium smegmatis on drug-containing agar, resistant colonies arose over a period of 2 weeks. A recA deficiency reduced mutant recovery, consistent with involvement of the SOS response in mutant induction. The C-8-methoxy compounds gatiflo...
متن کاملGallium(iii) and iron(iii) complexes of quinolone antimicrobials.
Iron is an essential nutrient for many microbes. According to the "Trojan Horse Hypothesis", biological systems have difficulties distinguishing between Fe(3+) and Ga(3+), which constitutes the antimicrobial efficacy of the gallium(iii) ion. Nine novel tris(quinolono)gallium(iii) complexes and their corresponding iron(iii) analogs have been synthesized and fully characterized. Quinolone antimic...
متن کاملResistance to antimicrobials in humans and animals.
Warning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s various reports had signalled the dangers of excessive or inappropriate use of antibiotics in clinical medicine and of the use of antibiotics in animal feed as growth promoters. Overuse of antimicrobials emerged as the main culprit, and reducing thei...
متن کاملQuinolone resistance in Campylobacter.
Sir, The Campylobacter Sentinel Surveillance Scheme Collaborators (CSSSC) highlight the importance of antimicrobial resistance in Campylobacter jejuni isolated in England and Wales, reiterating the previously described risk for quinolone resistance of foreign travel.1,2 Overall and foreign travel associated rates of quinolone resistance of 19% and 53% (noted as 55% in the abstract) are in keepi...
متن کاملQuinolone resistance mechanisms in pneumococci.
Quinolones are widely used in the treatment of respiratory infections, in large part because of their activity against Streptococcus pneumoniae and other commonly encountered respiratory tract pathogens. Pneumococcal isolates that are resistant to these "respiratory quinolones" have now begun to emerge. Resistance is attributable to mutations affecting the intracellular targets of these drugs, ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2012
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00474-12